When working with high-potency APIs and ultra-low doses, every dose matters. Manufacturers need a filling process that can deliver precise, consistent doses without compromising the powder, while providing flexibility to support low-volume cGMP manufacturing. 3P innovation’s Fill2Weight™ gravimetric filling technology is designed for exactly these challenges, enabling precise dosing of very small quantities of powder for inhalation, parenteral and oral solid dose (OSD) applications. The technology handles challenging powders without compaction, helping preserve the properties required for inhalation delivery and reducing the need for costly, time-consuming formulation development.
Fill2Weight™ is designed to support the journey from early clinical development through to commercial manufacture. Localized low-frequency vibration promotes smooth powder flow while minimizing blend segregation or damage. Every dose is weighed and verified, with out-of-spec doses rejected to support cGMP and Annex 1 requirements. With scalable core technology, customers can take the same fundamental filling approach through development and scale-up, avoiding the need to develop and validate new filling technologies at each stage. This can help customers reach first-in-human (FIH) milestones 2–3 months faster, gain earlier insight into drug efficacy and reduce the technical and financial burden of moving towards commercial production.
