Why Every Step Matters in Cryopreservation: A New Whitepaper for Cell & Gene Therapy Manufacturers
For cell and gene therapy manufacturers, successful cryopreservation is about more than achieving acceptable post-thaw viability. The real challenge is preserving the cellular functionality needed for downstream research, manufacturing, and therapeutic applications. This whitepaper explores how cryovial filling and cryopreservation workflows can be optimized to support more consistent and reproducible outcomes.
The whitepaper highlights a critical reality facing advanced therapy developers: once cryoprotectant is added, time becomes a key process variable. Manual handling, operator intervention, and inconsistent filling practices can introduce variability that ultimately impacts cell quality and performance.
To address these challenges, the paper examines an integrated approach that combines cryoFIL® automated cryovial filling with CELL controlled-rate freezing technology. Together, these technologies help reduce the time from cryoprotectant addition to freezing, automate critical filling operations, provide 100% weight verification, and support more consistent cryopreservation outcomes.
The whitepaper also reviews data demonstrating strong post-thaw viability and functional recovery using controlled-rate freezing methods, reinforcing the importance of considering the entire cryopreservation workflow, not just the freezing step alone.
For organizations developing cell and gene therapies, the paper provides valuable insights into:
- Reducing variability in cryovial filling workflows
- Improving process reproducibility through automation
- Preserving cell functionality beyond simple viability measurements
- Supporting scalable manufacturing and commercialization goals
- Optimizing the path from filling to cryopreservation
If you’re evaluating ways to improve cryopreservation performance, strengthen process control, or prepare manufacturing operations for scale, this whitepaper offers practical insights and real-world data worth exploring.
Download the full whitepaper:
Optimizing Cryovial Filling & Cryopreservation for Reliable Cell Functionality
Discover how an integrated approach to cryovial filling and controlled-rate freezing can help improve consistency, preserve functionality, and support the future of cell and gene therapy manufacturing.